Hemophilia A & B in Dogs
I’ve just been told that my dog has a disease called Hemophilia A. My veterinarian explained to me that this is one of several types of hemophilia dogs can experience. She mentioned both Hemophilia A and Hemophilia B. I understand that both Hemophilia A and Hemophilia B involve abnormal blood clotting, but I don’t really understand the details.
Hemophilia A is the most common of the inherited blood clotting disorders in dogs. It is the result of a spontaneous mutation of the specific gene that causes a deficiency of blood clotting Factor VIII (8). Factor VIII is important for normal blood clot formation. Once the gene responsible for Factor VIII mutates, the dog is incapable of producing functional Factor VIII, which interrupts and interferes with the blood clotting cascade.
How are dogs diagnosed with Hemophilia A?
Hemophiliacs may bleed spontaneously. They may bleed into their joints or muscles causing lameness. There is a chance these dogs may bleed into their chest cavity or abdomen causing death. Finally, hemophiliacs may be revealed during routine surgery if there is excessive, unexpected post-operative bleeding.
The laboratory test called APTT (activated partial thromboplastin time) is a screening test for clotting disorders, but cannot distinguish among the various types of hemophilia. The APTT must be performed on a specially prepared blood sample. Beyond the APTT, a specific diagnosis of Hemophilia A is made by measuring the activity of Factor VIII.
Are laboratory tests enough for me to know for sure that my dog has Hemophilia A? The veterinarian said my dog should not be bred, but it’s not not clear to me why not.
Because Hemophilia A (Factor VIII deficiency) is an inherited disease, it is important to understand the inheritance pattern. The gene for Factor VIII is carried on the X chromosome, making this a sex-linked recessive disease. This means that only one normal gene is needed to prevent Hemophilia A. Male dogs (XY) inherit one X chromosome (from their mother), and female dogs (XX) inherittwo X chromosomes (one from their mother and one from their father),
A male with one normal Factor VIII gene and a female with two normal Factor VIII genes are completely clear of Hemophilia A and cannot pass the disease along to any offspring.
A male with the abnormal Factor VIII gene on his only inherited X chromosome will himself have Hemophilia A and will transmit the abnormal gene to all of his daughters but none of his sons (the male offspring get their single X chromosome from the mother).
A female dog with one normal and one abnormal Factor VIII gene will not exhibit Hemophilia A, but will pass along the abnormal gene to ½ of both male and female puppies, on average.
Most commonly, when Hemophilia A is expressed in a line of dogs, it is passed along when asymptomatic females breed with normal males. From these pairings, about 50% of male offspring will have Hemophilia A, and about 50% of females will be carriers. Because of the heritability pattern of Hemophilia A, a laboratory analysis should be complemented with a pedigree analysis in order to develop breeding recommendations.
What about Hemophilia B?
Hemophilia B is caused by a deficiency of coagulation Factor IX (9) and has been found in over 25 breeds of dog. Like dogs with Hemophilia A, dogs with Hemophilia B may spontaneously bleed into the chest, abdomen, muscles, or joints. Also, there may be excessive bleeding from a surgery site. Compared with Hemophilia A, Hemophilia B tends to be a milder disease.
Like Hemophilia A, Hemophilia B is a sex-linked recessive trait. The gene for Factor IX is carried on the X chromosome, so the inheritance pattern is the same as that for Hemophilia A. The blood level of Factor IX can be measured in order to make the diagnosis of Hemophilia B.
Carriers of Hemophilia A and B do not themselves exhibit symptoms off blood clotting deficiencies, but they should not be used in breeding programs. Affected dogs cannot be cured. Following trauma or surgery, these dogs may need blood transfusions of whole blood or blood products that provide clotting factors. Hemophilia A and B are diseases that are best prevented, so screening of potential breeding animals is important.
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